Manchester United will face Chelsea at Old Trafford on November 3, with interim manager Ruud van Nistelrooy in charge as the club transitions to new leadership under Ruben Amorim, who officially takes over on November 11. United aim to bounce back in the Premier League after recent challenges, fielding a lineup that could see minor adjustments following a strong performance against Leicester​
Predictions suggest United will line up in a 4-2-3-1 formation. Goalkeeper Andre Onana is expected to start, supported by Diogo Dalot on the right and Noussair Mazraoui on the left. Lisandro Martinez and Matthijs de Ligt will likely handle central defense. In midfield, Casemiro and Manuel Ugarte provide stability, with Bruno Fernandes in the attacking role and wingers Marcus Rashford and Alejandro Garnacho looking to create chances. Up front, Rasmus Hojlund could replace Joshua Zirkzee as the central striker
Chelsea, managed by Enzo Maresca, brings a youthful and dynamic lineup, focusing on counter-attacks. They are expected to use a similar 4-2-3-1 setup, with Robert Sanchez in goal, supported by a defense featuring Reece James, Wesley Fofana, Levi Colwill, and Marc Cucurella. Midfielders Moises Caicedo and Romeo Lavia are expected to start, with Cole Palmer, Noni Madueke, and Pedro Neto supporting Nicolas Jackson as the lone forward​
This matchup is highly anticipated, with both teams needing points to strengthen their positions in the Premier League and continue their respective quests for European qualification.